Inside the World’s First Successful 3D Bioprinted Human Cornea Transplant

In October 2025, Rambam Health Care Campus in Haifa, Israel, marked a world first with the successful transplantation of a fully 3D bioprinted corneal implant, created entirely in the lab from living human cells. Developed by Precise Bio, the implant was produced using a platform capable of expanding a single donor cornea into up to 300 transparent, layered corneal structures designed to replicate the function of a healthy human cornea without the need for additional donor tissue. The procedure, performed at the Rambam Eye Institute as part of an ongoing Phase 1 clinical trial, restored vision in a patient who was legally blind in the treated eye. This milestone represents a significant step forward in addressing the global shortage of donor corneas and offers new hope to millions affected by corneal blindness. To better understand the technology and its implications, we spoke with Aryeh Batt, CEO and Co-Founder of Precise Bio.

3DN: Could you introduce yourself and share what led you into 3D printing and co-founding Precise Bio?

CEO and Co-Founder Aryeh Batt

My professional background is physics, mainly in the electro-optics field. I have held positions in the Israeli hi-tech industry from R&D to executive management and led multi-disciplinary products from development to sales and marketing. I developed a unique 3D printing technology that can ‘print’ human cells at high viability, enabling the structuring of human tissue and organs comprised of human cells and natural materials mimicking the functionality and structure of the human tissue. When I understood the revolution we can bring in healthcare, I decided to establish Precise Bio with Dr. Anthony Atala, the director of the Wake Forest Institute of Regenerative Medicine (WFIRM), a leader and pioneer in the tissue engineering arena, and Prof. Shay Soker (also from WFIRM), a molecular biologist and a leading scientist in the field.

3DN: What is Precise Bio’s mission?

Precise Bio envisions a future where patients no longer wait for life-saving transplants, and unmet critical therapeutic needs are solved using Precise Bio’s natural, hyper-accurate bio-fabrication technology. The company fabricates natural tissues for transplant in patients, addressing needs where there is a lack of donor tissue or in cases where there is a therapeutic need. Replacing a damaged tissue with a new bio-fabricated tissue can solve the unmet need.