Researchers reproduce the surface of a human tongue thanks to 3D printing

Researchers at the University of Leeds, in collaboration with Edinburgh University, have 3D printed soft synthetic surfaces with the same texture as a human tongue. Made of silicone, they could mimic the topology, elasticity and wettability of this complex organ. An innovation that could open up new possibilities in terms of testing the properties of food, pharmaceuticals and also help to better understand certain reactions (such as dry mouth) without having to do it on a human being.

The tongue is a complex organ composed of several muscles, highly vascularised and capable of transmitting taste thanks to its many taste buds. These cover the whole of the tongue, and allow us to perceive five tastes: sweet, salty, sour, bitter, umami, the rest being perceived by the sense of smell. These papillae give the tongue a very special surface, which is not easy to reproduce. However, researchers at the University of Leeds have taken up the challenge and opted for 3D printing.

The structure of the human tongue is complex | Credits: Anwesha Sarkar

Dr. Efren Andablo-Reyes, Director of Research, explains: “Recreating the surface of an average human tongue comes with unique architectural challenges. Hundreds of small bud-like structures called papillae give the tongue its characteristic rough texture which, combined with the soft nature of the fabrics, creates a mechanically complicated landscape. We have sought to reproduce the important mechanical characteristics of the human tongue (i.e. the pleasant perception of the oral sensation and adequate lubrication for swallowing) in a surface that is easy to use in the laboratory to reproduce the conditions of oral treatment.”